|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The restricted V(H) gene usage in anticolon autoantibodies producing B-cell clones suggests that a particular antigenic stimulus contributes to the pathogenesis of UC.
|
11438490 |
2001 |
|
Thyroid Lymphoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
DNA sequence of immunoglobulin heavy chain variable region gene in thyroid lymphoma.
|
11676854 |
2001 |
|
Stereotypic Movement Disorder
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Immunoglobulin heavy chain variable region gene repertoire and B-cell receptor stereotypes in Indian patients with chronic lymphocytic leukemia.
|
26942309 |
2016 |
|
Sporadic Burkitt's lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However the level of somatic mutation and the effect of antigen selection on V(H) gene were diverse in these three cases, and the relationship between V(H) gene somatic mutation status and intraclonal diversity was unclear in sBL.
|
11908722 |
2002 |
|
Rheumatoid Arthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Biased usage of synovial immunoglobulin heavy chain variable region 4 by the anti-glucose-6-phosphate isomerase antibody in patients with rheumatoid arthritis.
|
17611644 |
2007 |
|
Rheumatoid Arthritis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
A relationship between these secondary V(H) gene rearrangements and the autoimmunity characteristic of RA should be considered.
|
11034605 |
2000 |
|
Rheumatoid Arthritis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of immunoglobulin heavy-chain variable region genes from the synovium of a rheumatoid arthritis patient shows little evidence of mutation but diverse CDR3.
|
7751018 |
1995 |
|
Rheumatoid Arthritis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
To investigate the contribution of polymorphism in the immunoglobulin heavy chain variable region V1-69 gene set to genetic susceptibility to rheumatoid arthritis (RA) in Czech and British patients.
|
11961170 |
2002 |
|
Pyothorax-Associated Lymphoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
DNA sequences of the immunoglobulin heavy chain variable region gene in pyothorax-associated lymphoma.
|
12065872 |
2002 |
|
Pseudotumor Cerebri
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the hypothesis that pseudotumor cerebri (PTC) is associated with humoral immunity, we analyzed immunoglobulin heavy chain variable region (Ig-VH) genes of B cells in the cerebrospinal fluid (CSF) of 10 patients with PTC.
|
15622452 |
2004 |
|
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Importantly, we confirmed by multivariate analysis that this was independent of IgHV mutational status or subset #2 stereotyped receptor (<i>P</i> < 0.0001).<b>Conclusions:</b> We have demonstrated for the first time that a light chain can affect CLL prognosis and that IgLV3-21 light chain usage defines a new subgroup of CLL patients with poor prognosis.<i>Clin Cancer Res; 24(20); 5048-57.©2018 AACR</i>.
|
29945996 |
2018 |
|
Precursor B-cell lymphoblastic leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The lack of mutation in VH gene sequences suggests that SM may differ between PB-LBL and B-ALL.
|
11710683 |
2001 |
|
Precursor B-cell lymphoblastic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate whether immunoglobulin heavy chain FR-derived peptides shared in each IgHV family are potential CTL epitopes presented by B-cell acute lymphoblastic leukemia (B-ALL).
|
17517179 |
2007 |
|
Plasmacytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sequences required for the function of the mouse V1 immunoglobulin heavy chain variable-region (VH) promoter were identified by transient transfection of the normal and mutated promoters into plasmacytoma cells.
|
3118372 |
1987 |
|
Papillary thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the hypothesis that pseudotumor cerebri (PTC) is associated with humoral immunity, we analyzed immunoglobulin heavy chain variable region (Ig-VH) genes of B cells in the cerebrospinal fluid (CSF) of 10 patients with PTC.
|
15622452 |
2004 |
|
Pancreatitis due to pancreatic duct obstruction
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the rate of unmutated VH fragments in type 1 AIP (17%) was higher than that in obstructive pancreatitis (5.1%) (P= 0.010).
|
22524659 |
2012 |
|
Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sequence analysis of VH genes showed that an autoimmune mechanism may be involved in the lymphomagenesis of ocular adnexal MALT lymphoma.
|
11454995 |
2001 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The tumor immunoglobulin heavy chain variable region was more frequently unmutated in CLL cells of LR patients, and the mevalonate pathway, which generates Vγ9Vδ2 TCR ligands, was more active in unmutated CLL cells.
|
22932792 |
2012 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias.
|
1700749 |
1990 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
The immunoglobulins secreted by these cell lines reacted variably with a panel of anti-idiotypic antibodies, indicating that the tumor was heterogeneous; however, one antibody, 4D6, reacted strongly with the product of all the heterohybridomas. cDNA for the immunoglobulin heavy chain variable-region genes expressed in these heterohybridomas was cloned and sequenced.
|
3496601 |
1987 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
We have previously shown that the cytogenetic breakpoints of one t(14;14)(q11;q32) chromosome and two inv(14)(q11;q32) chromosomes in T-cell tumors from AT and non-AT patients join the T-cell receptor alpha chain locus, at chromosome band 14q11, with a region(s) at 14q32 centromeric of the immunoglobulin heavy chain variable region (VH) gene IGHV.
|
3194418 |
1988 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In the other two patients, a similar VH band pattern was observed and also was compared using direct sequencing, which demonstrated sequence differences between tumors from the two sites.
|
15372481 |
2004 |
|
Multiple Sclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region.
|
1672695 |
1991 |
|
Multiple Sclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region.
|
8568530 |
1995 |
|
Multiple Sclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Immunoglobulin heavy chain variable region polymorphisms and multiple sclerosis susceptibility.
|
8496340 |
1993 |